Multimedia
Completely locked-in man uses brain-computer interface to communicate
The study, published in Nature Communications, paves the way for new technologies for people with severe paralysis.
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Revealing 3D anatomy with lightsheet microscopy
Microscopy is experiencing a revolution. Developers around the world are pushing microscope technology to the extremes.
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Creating transparent brains
New laboratory techniques are helping us understand disease mechanisms in the brain, but what are these techniques and how do they work?
Find out moreImage of the month: innovative computational solutions for real-world biological data
A collaboration between the Wyss Center, University of Geneva/Unit of anatomy, and TU Dresden/Center for Systems Biology Dresden is exploring efficient algorithms for image-based biology with large datasets. The team has focused on new algorithms to reduce the memory footprint and accelerate analysis of very large datasets acquired in our microscopy facility, in real time. Known as pAPRica, the innovative computational imaging pipeline reduces the memory and compute costs of light-sheet microscopy data by about 100x, and it can scale to process PetaByte-sized datasets.
Fluorescent image of a thick human brain sample acquired using pAPRica. Credit: Wyss Center / Lamy lab - Human Brain Mapping project / TU Dresden / MPI-CBG / CSBD
Expansion microscopy: A technique to visualize the intricacies of the brain
Expansion microscopy deepens our understanding of disease mechanisms to accelerate development of therapies for neurological and psychiatric disorders, like Parkinson’s and Alzheimer’s diseases. Chemical anchors in expanding gel attach to biomolecules, physically expanding the brain sample and allowing as much information as possible to be extracted from the tissue.
ABILITY enters preclinical trial
A preclinical trial is underway with the ABILITY brain-computer interface system.
The study, which is being carried out in sheep, is a crucial step towards development of a fully implantable device to enable applications such as communication and movement for people with paralysis.
The trial will assess the safety and feasibility of brain signal recording and wireless transfer of neural data to a wearable computer.
The ABILITY device and an X-ray view of the device when implanted.
Where I work: Seeing the invisible
Research technician Ivana Gantar explores the hidden microscopic world within mammalian brains using the latest lightsheet microscope technology.
ALICe: State-of-the-art advanced lightsheet imaging center
Whole central nervous system lightsheet imaging of motor circuit and 3D surface rendering (Asboth et al. 2018). Courtine Lab, EPFL
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