Advancing our understanding of the brain's complex circuitry
The physical and biological complexity of the human brain has posed a significant challenge in the success of neuroscience research and development. As critical as it is to develop solutions that reach the clinic, it also imperative that we enhance our basic understanding of the human brain in health and disease so that we can develop tools and approaches that increase our efficiency and chances of successful discovery and therapies.
Defining the future of neuroscience discovery
We seek to develop approaches that can enable and enhance our understanding of the brain, the nervous system and brain disease mechanisms, in an organized, systematic and effective way.
To that end, part of our research efforts and collaborations are focused on achieving large scale, high-content brain circuit mapping of both basic and clinical relevance. Benefiting from major advances in chemistry and genetics, we seek to help advance new methods for brain mapping and contribute to the world’s ability to see the brain in full molecular and cellular detail.
This should have implications for all areas of basic and applied neuroscience, and should directly inform potential new therapies, whether drug- based, gene therapy- based or device- based. Hence, we also pursue the development of highly specific gene or cell therapies for specific indications such as dementia, stroke and spinal cord injury.
Key neurobiology areas of development at the Wyss Center:
- Brain mapping: tissue processing / histology, genetic engineering, hardware, human tissue slice culture, organoids, computational analysis and image processing.
- Molecular biology and microscopy
- Cell and gene therapy: collaborating with external research groups and facilities on the development and optimization of pre-clinical and clinical protocols and trials
- Data collection and management
- Obtaining and banking human tissue samples
Our existing facilities and expertise in microscopy, histology and cell culture, and molecular biology will contribute to our expansion into the field of neurobiology.
Study contributes to our understanding of how cocaine withdrawal affects brain circuits
The results could help clinicians understand addiction and enable people to better manage substance withdrawal.Collaboration
Shining a light on neurodegenerative disorders
Could a ray of light stop rogue proteins in their tracks and slow the spread of neurodegenerative disease in the brain? EPFL and the Wyss Center are set to find out.Collaboration
Wyss Center joins Wellcome Leap global network dedicated to accelerated breakthroughs in human health
Charter group of 21 world-class institutions representing a network of over 150,000 researchers across six continents sign agreement that sets new bar for fast-paced research and development.Collaboration