Stéphane's expertise in innovative optical approaches is instrumental in the continued development and customization of the Wyss Center's advanced imaging facility.
Stéphane joined the Wyss Center in June 2016. He oversaw the setting up of an advanced imaging facility based on innovative optical approaches. The first microscope that he has built was a Clarity Optimized Lightsheet Microscope (COLM) for whole brain imaging at subcellular resolution. This was followed by the construction of a mesoscale Single Plane Illumination Microscope (mesoSPIM – mesoSPIM.org). Finally, he contributed to the emergence of the Advanced Light Sheet Imaging Center (ALICe), an entire pipeline dedicated to clarification and high-resolution imaging of tissue.
Stéphane is also a Senior Research Assistant in the Department of Fundamental Neurosciences at the Faculty of Medicine of Geneva. After his PhD in ultrafast spectroscopy and non-linear optics at the UNIGE Science Department, he joined the Neurophotonics Center at Laval University, Canada as a FNS postdoctoral fellow where he developed new optical approaches to optically record membrane potential changes and calcium dynamics in dendritic spines.
He also participated in the development of an autofocus device for two-photon microscopes to image calcium dynamics in the spinal cord of living rodents. In 2011, he joined the Anthony Holtmaat’s team at UNIGE to pursue his research on neuronal functional and structural plasticity in vivo.
Study contributes to our understanding of how cocaine withdrawal affects brain circuits
The results could help clinicians understand addiction and enable people to better manage substance withdrawal.Collaboration
Peeking inside ‘mini-brains’ could boost understanding of the human brain in health and disease
Revealing details of the internal structure of ‘mini-brains’ could help accelerate drug studies and may offer alternatives to some animal testing.Collaboration
New microscopes to unravel the mysteries of brain organization
Researchers around the world share their stunning images and insights: The open source mesoSPIM Initiative.Collaboration