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Projects

Finding cures for the future in the brains of the past

Brain mapping: Uniting multi-scale brain data to reveal disease mechanisms

PROJECT OVERVIEW

Goal  |  improving data to map the brain

Status  |  Completed

Timeframe  |  –

Area of Research  |  Neuro visualization technology

Partners  |  HUG, UNIGE

Lead  |  Christophe Lamy

Evolution  |  spun out as DataFlight Solutions Ltd.

CONTACT

The challenge

In the past it has been difficult to reconcile advances made at a cellular level with a whole-brain approach. This collaborative project combines cellular resolution data with whole-brain information to provide genuinely new insights into the pathological mechanisms underlying human brain disorders.

For decades the microscopic study of brain tissue has helped pathologists understand disease, describe the cellular diversity of the nervous system and define specific features of brain disorders. In parallel, neuroimaging methods have revealed the function and dysfunctions of whole brain neural circuits. However, technical limitations of traditional microscopy have made it difficult to relate cellular level advances to whole brain observations. Our approach unifies neuroscience across scales, from genes to the whole brain, with the goal of revealing the mechanisms of brain disease, establishing diagnostic biomarkers and identifying new therapeutic targets.

Partners